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A global genetic interaction network maps a wiring diagram of cellular function

机译：全球遗传相互作用网络绘制了细胞功能的接线图

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摘要

We generated a global genetic interaction network for Saccharomyces cerevisiae, constructing more than 23 million double mutants, identifying about 550,000 negative and about 350,000 positive genetic interactions. This comprehensive network maps genetic interactions for essential gene pairs, highlighting essential genes as densely connected hubs. Genetic interaction profiles enabled assembly of a hierarchical model of cell function, including modules corresponding to protein complexes and pathways, biological processes, and cellular compartments. Negative interactions connected functionally related genes, mapped core bioprocesses, and identified pleiotropic genes, whereas positive interactions often mapped general regulatory connections among gene pairs, rather than shared functionality. The global network illustrates how coherent sets of genetic interactions connect protein complex and pathway modules to map a functional wiring diagram of the cell.
机译：我们为酿酒酵母（Saccharomyces cerevisiae）生成了一个全球遗传相互作用网络，构建了超过2300万个双突变体，鉴定出约55万个阴性和约35万个阳性遗传相互作用。这个全面的网络绘制了必不可少的基因对的遗传相互作用图，突出了必不可少的基因作为密集连接的枢纽。遗传相互作用谱使得能够组装细胞功能的分层模型，包括与蛋白质复合物和途径，生物过程和细胞区室相对应的模块。负向相互作用连接功能相关的基因，绘制核心生物过程，并鉴定多效性基因，而正向相互作用通常绘制基因对之间的一般调节联系，而不是共有功能。全球网络说明了连贯的遗传相互作用集如何连接蛋白质复合物和途径模块，以绘制细胞的功能接线图。

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  • 来源
    《Science》 |2016年第6306期|1381-1381|共1页
  • 作者

    Costanzo Michael; VanderSluis Benjamin; Koch Elizabeth N.; Baryshnikova Anastasia; Pons Carles; Tan Guihong; Wang Wen; Usaj Matej; Hanchard Julia; Lee Susan D.; Pelechano Vicent; Styles Erin B.; Billmann Maximilian; van Leeuwen Jolanda; van Dyk Nydia; Lin Zhen-Yuan; Kuzmin Elena; Nelson Justin; Piotrowski Jeff S.; Srikumar Tharan; Bahr Sondra; Chen Yiqun; Deshpande Raamesh; Kurat Christoph F.; Li Sheena C.; Li Zhijian; Usaj Mojca Mattiazzi; Okada Hiroki; Pascoe Natasha; San Luis Bryan-Joseph; Sharifpoor Sara; Shuteriqi Emira; Simpkins Scott W.; Snider Jamie; Suresh Harsha Garadi; Tan Yizhao; Zhu Hongwei; Malod-Dognin Noel; Janjic Vuk; Przulj Natasa; Troyanskaya Olga G.; Stagljar Igor; Xia Tian; Ohya Yoshikazu; Gingras Anne-Claude; Raught Brian; Boutros Michael; Steinmetz Lars M.; Moore Claire L.; Rosebrock Adam P.; Caudy Amy A.; Myers Chad L.; Andrews Brenda; Boone Charles;

  • 作者单位

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Minnesota Twin Cities, Dept Comp Sci & Engn, 200 Union St, Minneapolis, MN 55455 USA|Simons Fdn, Simons Ctr Data Anal, 160 Fifth Ave, New York, NY 10010 USA;

    Univ Minnesota Twin Cities, Dept Comp Sci & Engn, 200 Union St, Minneapolis, MN 55455 USA;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA;

    Univ Minnesota Twin Cities, Dept Comp Sci & Engn, 200 Union St, Minneapolis, MN 55455 USA|Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Barcelona, Catalonia, Spain;

    Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA;

    Univ Minnesota Twin Cities, Dept Comp Sci & Engn, 200 Union St, Minneapolis, MN 55455 USA;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Tufts Univ, Sch Med, Dept Dev Mol & Chem Biol, Boston, MA 02111 USA;

    European Mol Biol Lab EMBL, Genome Biol Unit, D-69117 Heidelberg, Germany|Karolinska Inst, Sci Life Lab, Dept Microbiol Tumor & Cell Biol, Solna, Sweden;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    German Canc Res Ctr, Div Signaling & Funct Genom, Heidelberg, Germany|Heidelberg Univ, Heidelberg, Germany;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Minnesota Twin Cities, Dept Comp Sci & Engn, 200 Union St, Minneapolis, MN 55455 USA|Univ Minnesota Twin Cities, Program Biomed Informat & Computat Biol, 200 Union St, Minneapolis, MN 55455 USA;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|RIKEN, Ctr Sustainable Resource Sci, Chem Genom Res Grp, Saitama, Japan|Yuman Therapeut, 790 Mem Dr, Cambridge, MA 02139 USA;

    Univ Toronto, Princess Margaret Canc Ctr, Univ Hlth Network, Toronto, ON, Canada|Univ Toronto, Dept Med Biophys, Toronto, ON, Canada|Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Minnesota Twin Cities, Dept Comp Sci & Engn, 200 Union St, Minneapolis, MN 55455 USA;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Francis Crick Inst, Clare Hall Lab, S Mimms EN6 3LD, Herts, England;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|RIKEN, Ctr Sustainable Resource Sci, Chem Genom Res Grp, Saitama, Japan;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Tokyo, Grad Sch Frontier Sci, Dept Integrated Biosci, Kashiwa, Chiba 2778561, Japan;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Minnesota Twin Cities, Dept Comp Sci & Engn, 200 Union St, Minneapolis, MN 55455 USA|Univ Minnesota Twin Cities, Program Biomed Informat & Computat Biol, 200 Union St, Minneapolis, MN 55455 USA;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    UCL, Dept Comp Sci, London WC1E 6BT, England;

    Imperial Coll London, Dept Comp, London, England;

    UCL, Dept Comp Sci, London WC1E 6BT, England|Union Univ, Sch Comp RAF, Belgrade, Serbia;

    Simons Fdn, Simons Ctr Data Anal, 160 Fifth Ave, New York, NY 10010 USA|Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Biochem, Toronto, ON, Canada;

    Univ Minnesota Twin Cities, Dept Comp Sci & Engn, 200 Union St, Minneapolis, MN 55455 USA|Huazhong Univ Sci & Technol, Sch Elect Informat & Commun, Wuhan 430074, Peoples R China;

    Univ Tokyo, Grad Sch Frontier Sci, Dept Integrated Biosci, Kashiwa, Chiba 2778561, Japan;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada;

    Univ Toronto, Princess Margaret Canc Ctr, Univ Hlth Network, Toronto, ON, Canada|Univ Toronto, Dept Med Biophys, Toronto, ON, Canada;

    German Canc Res Ctr, Div Signaling & Funct Genom, Heidelberg, Germany|Heidelberg Univ, Heidelberg, Germany;

    European Mol Biol Lab EMBL, Genome Biol Unit, D-69117 Heidelberg, Germany|Stanford Univ, Sch Med, Dept Genet, Palo Alto, CA 94304 USA|Stanford Univ, Stanford Genome Technol Ctr, Palo Alto, CA 94304 USA;

    Tufts Univ, Sch Med, Dept Dev Mol & Chem Biol, Boston, MA 02111 USA;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Minnesota Twin Cities, Dept Comp Sci & Engn, 200 Union St, Minneapolis, MN 55455 USA|Univ Minnesota Twin Cities, Program Biomed Informat & Computat Biol, 200 Union St, Minneapolis, MN 55455 USA;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada;

    Univ Toronto, Donnelly Ctr, 160 Coll St, Toronto, ON M5S 3E1, Canada|Univ Toronto, Dept Mol Genet, 160 Coll St, Toronto, ON M5S 3E1, Canada|RIKEN, Ctr Sustainable Resource Sci, Chem Genom Res Grp, Saitama, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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  • 入库时间 2022-08-18 02:51:45

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