• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Science >Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques
【24h】

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

机译：三特异性广泛中和HIV抗体介导猕猴对SHIV的有效保护

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The development of an effective AIDS vaccine has been challenging because of viral genetic diversity and the difficulty of generating broadly neutralizing antibodies (bnAbs). We engineered trispecific antibodies (Abs) that allow a single molecule to interact with three independent HIV-1 envelope determinants: the CD4 binding site, the membrane-proximal external region (MPER), and the V1V2 glycan site. Trispecific Abs exhibited higher potency and breadth than any previously described single bnAb, showed pharmacokinetics similar to those of human bnAbs, and conferred complete immunity against a mixture of simian-human immunodeficiency viruses (SHIVs) in nonhuman primates, in contrast to single bnAbs. Trispecific Abs thus constitute a platform to engage multiple therapeutic targets through a single protein, and they may be applicable for treatment of diverse diseases, including infections, cancer, and autoimmunity.
机译：由于病毒的遗传多样性和产生广泛中和抗体（bnAbs）的困难，有效的艾滋病疫苗的开发一直具有挑战性。我们设计了三特异性抗体（Abs），该抗体可以使单个分子与三个独立的HIV-1包膜决定簇相互作用：CD4结合位点，膜近端外部区域（MPER）和V1V2聚糖位点。与单个bnAb相比，三特异性Abs具有比任何先前描述的单个bnAb更高的效力和广度，显示出与人bnAb相似的药代动力学，并赋予其在非人灵长类动物中对猿猴-人免疫缺陷病毒（SHIV）混合物的完全免疫力。因此，三特异性抗体构成了一个平台，可以通过一种蛋白质与多个治疗靶标结合，它们可能适用于治疗多种疾病，包括感染，癌症和自身免疫。

著录项

  • 来源
    《Science》 |2017年第6359期|85-90|共6页
  • 作者

    Xu Ling; Pegu Amarendra; Rao Ercole; Doria-Rose Nicole; Beninga Jochen; Mckee Krisha; Lord Dana M.; Wei Ronnie R.; Deng Gejing; Louder Mark; Schmidt Stephen D.; Mankoff Zachary; wu Lan; Asokan Mangaiarkarasi; Beil Christian; Lange Christian; Leuschner Wulf Dirk; Kruip Jochen; Sendak Rebecca; Do Kwon Young; Zhou Tongqing; Chen Xuejun; Bailer Robert T.; Wang Keyun; Choe Misook; Tartaglia Lawrence J.; Barouch Dan H.; ODell Sijy; Todd John-Paul; Burton Dennis R.; Roederer Mario; Connors Mark; Koup Richard A.; Kwong Peter D.; Yang Zhi-yong; Mascola John R.; Nabel Gary J.;

  • 作者单位

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    Harvard Med Sch, Ctr Virol & Vaccine Res, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA|Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA;

    Harvard Med Sch, Ctr Virol & Vaccine Res, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA|Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    Ragon Inst MGH MIT & Harvard, Cambridge, MA 02139 USA|Scripps Res Inst, Dept Immunol & Microbiol, Int AIDS Vaccine Initiat IAVI Neutralizing Antibo, Ctr HIV AIDS Vaccine Immunol & Immunogen Discover, La Jolla, CA 92037 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

    NIAID, Vaccine Res Ctr, 9000 Rockville Pike, Bethesda, MD 20892 USA;

    Sanofi, 640 Mem Dr, Cambridge, MA 02139 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-18 02:51:24

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号