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Quantitative analysis of population-scale family trees with millions of relatives

机译:数百万亲属的人口规模家谱的定量分析

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摘要

Family trees have vast applications in fields as diverse as genetics, anthropology, and economics. However, the collection of extended family trees is tedious and usually relies on resources with limited geographical scope and complex data usage restrictions. We collected 86 million profiles from publicly available online data shared by genealogy enthusiasts. After extensive cleaning and validation, we obtained population-scale family trees, including a single pedigree of 13 million individuals. We leveraged the data to partition the genetic architecture of human longevity and to provide insights into the geographical dispersion of families. We also report a simple digital procedure to overlay other data sets with our resource.
机译:家谱在遗传学,人类学和经济学等各个领域都有广泛的应用。但是,扩展家族树的收集很繁琐,通常依赖于地理范围有限且数据使用限制复杂的资源。我们从家谱爱好者共享的公开在线数据中收集了8600万张个人资料。经过广泛的清洁和验证,我们获得了人口规模的家谱,其中包括一个1300万个人的家谱。我们利用这些数据来划分人类寿命的遗传结构,并提供有关家庭地理分布的见解。我们还报告了一种简单的数字过程,可将其他数据集与我们的资源重叠。

著录项

  • 来源
    《Science》 |2018年第6385期|171-175|共5页
  • 作者单位

    New York Genome Ctr, New York, NY 10013 USA;

    New York Genome Ctr, New York, NY 10013 USA;

    MyHeritage, IL-6037606 Or Yehuda, Israel;

    Weizmann Inst Sci, Comp Sci Dept, IL-7610001 Rehovot, Israel;

    Technion Israel Inst Technol, Comp Sci Dept, IL-3200003 Haifa, Israel;

    New York Genome Ctr, New York, NY 10013 USA;

    Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA;

    Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA;

    Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA;

    New York Genome Ctr, New York, NY 10013 USA;

    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA;

    Harvard Med Sch, Boston, MA 02115 USA;

    Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA;

    New York Genome Ctr, New York, NY 10013 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

  • 入库时间 2022-08-18 02:51:08

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