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Studying associations between urinary metabolites of polycyclic aromatic hydrocarbons (PAHs) and cardiovascular diseases in the United States

机译:在美国研究多环芳烃(PAHs)的尿代谢物与心血管疾病之间的关联

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摘要

The association between background, enduring environmental exposure to polycyclic aromatic hydrocarbons (PAHs) and cardiovascular diseases has not been well studied in the general population. In this study, we used the National Health and Nutrition Examination Survey (NHANES) 2001-2004 to investigate the associations between eight monohydroxy PAHs (OH-PAHs) and self-report CVD. In a logistic regression model adjusting for cigarette smoking and other covariates, phenanthrene metabolite, 2-hydroxyphenna-threne (2-PHEN), was significantly associated with self-report CVD. Compared to subjects within the lowest fertile of 2-PHEN, subjects within the middle and highest tertiles had higher self-report CVD (the 2nd tertile: AOR= 1.29.95%CI: 0.97-1.72; the 3rd tertile: AOR= 1.45,95%Cl: 1.01-2.07; p for trend = 0.04). In addition, fluorene metabolite (i.e. 2-hydroxyfluorene) also showed a marginally significant linear trend with self-report CVD (p for trend = 0.07). Further studies are necessary to explore the associations between these highly prevalent pollutants and CVD.
机译:在普通人群中,背景,持久性环境暴露于多环芳烃(PAHs)与心血管疾病之间的关联尚未得到很好的研究。在这项研究中,我们使用2001-2004年美国国家健康和营养调查(NHANES)调查了八种单羟基PAH(OH-PAH)与自报告CVD之间的关联。在针对吸烟和其他协变量进行调整的逻辑回归模型中,菲代谢物2-羟基苯并菲(2-PHEN)与自我报告CVD显着相关。与处于2-PHEN最低生育水平的受试者相比,处于中等和最高三分位数的受试者的自我报告CVD较高(第二个三分位数:AOR = 1.29.95%CI:0.97-1.72;第三个三分位数:AOR = 1.45, 95%Cl:1.01-2.07;趋势p = 0.04)。此外,芴代谢物(即2-羟基芴)在自报告CVD中也显示出很小的线性趋势(趋势p = 0.07)。有必要进行进一步的研究以探索这些高度普遍的污染物与CVD之间的关联。

著录项

  • 来源
    《Science of the total environment》 |2010年第21期|p.4943-4948|共6页
  • 作者单位

    Department of Epidemiology and Biostatistics, College of Public Health and Health Professions, University of Florida, United States;

    rnDepartment of Epidemiology and Biostatistics, College of Public Health and Health Professions, University of Florida, United States;

    rnDepartment of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, United States;

    rnSchool of Public Health, Fudan University, Shanghai, China;

    rnDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, United States;

    rnNational Center for Environmental Health, Centers for Disease Control and Prevention, United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    polycyclic aromatic hydrocarbons (PAHs); cardiovascular diseases (CVD); NHANES; OH-PAHs; environmental exposure;

    机译:多环芳烃(PAHs);心血管疾病(CVD);HAN OH-PAHs;环境暴露;
  • 入库时间 2022-08-17 13:56:24

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