Exposure and Prioritization-Human Screening Data and Methods for High Production Volume Chemicals in Consumer Products: Amine Oxides a Case Study

摘要

Use and exposure data have been compiled and provided for HPV ingredients in consumer products allowing exposure screening. Indeed the general equations and habits and practices data can be reapplied to any chemical of interest in these product types, as long as estimates of IC could be developed. As stated in the general approach section of this document, this risk screening methodology is based on default maximum product exposure estimates and conservative dose-response data (i.e., the most relevant NOAEL and route-specific data when available), with the option to refine the assessment. The main purpose of this methodology is to serve as a priority-setting tool. The screening exposure and risk characterization outputs from the application of this methodology can help focus resources to develop more refined risk assessments where such refinement is needed, and assist in deciding where exposures/risks are of minimal concerns and refined assessment is not warranted.