Development of interventional whole body hyperthermia system: Part I: Device fabrication and performance evaluation

摘要

The whole body hyperthermia (WBH) is being regarded as a very promising way capable of efficiently treating patient with tumors already disseminated throughout the human body. However, there is currently a strong lack of an easy to administrate, highly efficient and minimally invasive heating strategy. In this paper, aiming to tackle such a bottle neck issue, the interventional whole body hyperthermia (IWBH) system through directly heating the blood flow via minimally invasive heating needle was successfully developed for the first time. As the first part of the present companying research, this paper was dedicated to illustrate in detail the device construction, and to test its heating capability with a series of simulating experiments. Comprehensive evaluations demonstrated that the new device is highly efficient, easy to administrate and reliable in raising patient’s body core temperature. Specially, the physical simulation experiments performed in the current study present a new perspective on studying the behavior of the temperature response of the human body subjected to endovascular heating. The animal test will be reported in our another companying paper.