Synthesis, chemical stability and application of a thiohydroxamic acid linker (THA) for solid-phase organic synthesis

摘要

The synthesis and chemical compatibility of a 'traceless' thiohydroxamic acid (THA) linker is reported. The linker is shown to be stable to visible light and heat. This paper also describes preliminary work in the application of the THA linker to act as a polymer-supported source of radicals.