Photopolymerized Patterning and Materials to Enhance Neural Prosthetic Performance

摘要

The described research presents a radiation-curing method to generate physical micropatterns in biomaterials and demonstrates the first use of topographic cues to align neurites of neurons from the inner ear. It is anticipated that the results of this interdisciplinary effort will contribute significantly to polymer neural regeneration technology and will lead to novel clinical techniques to improve CIs and, consequently, the quality of life for CI patients. Further, the knowledge gained about peripheral nervous system growth on these engineered biomaterials may improve existing or future therapies to treat PNS damage and may also enhance other facets of tissue engineering.