Two Techs In One Yields High Flow, High Ionization

摘要

With the Ultrasensitive Electrospray Ionization Mass Spectrometry Source and Interface, scientists from Pacific Northwest National Laboratory, Rich-land, Wash., combined a multi-nanoelectrospray ionization source (ESI) with a multi-inlet mass spectrometry (MS) interface. Thernunion of these two technologies provides ionization efficiencies that were before only achievable from very-low-flow-rate, specialized separations. Now it can be used with common, higher-flow-rate analyses.rnThe combination's main advantage is its 100% liquid chromatography effluent use efficiency as opposed to 5% for a conventional ESI source. The Ultrasensitive ESI-MS Source and Interface provides at least a 40-fold increase in MS sensitivity relative to commercially available instrumentation. Other results include improved operation, sensitivity, and quantitation for liquid samples and from liquid chromatography separations. Applications include materials analyses of pharmaceuticals or petrochemicals.