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The natural history of gluten sensitivity: defining, refining and re-defining

机译:面筋敏感性的自然史:定义,细化和重新定义

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摘要

Samuel Gee's essay of 1888 was a perfect description of advanced coeliac disease. This simple, yet well-observed, image was altered in the 1950s with the discovery that gluten protein causes the disease, and in the 1960s when peroral jejunal biopsies allowed first sight of the typical flat-destructive mucosal lesion, with marked crypt hypertrophy and complete villous effacement in patients with malab-sorption. The combination of a gluten-free diet and follow-up jejunal biopsies demonstrated the eventual restoration of normal mucosal architecture, thus lending to contemporary definitions a fairly strict requirement for mucosal healing.
机译:塞缪尔·基(Samuel Gee)在1888年发表的论文完美地描述了晚期腹腔疾病。在1950年代发现麸质蛋白引起该疾病后,这种简单而又易于观察的图像发生了变化,在1960年代,经空肠空肠活检首次见到典型的扁平破坏性粘膜病变,伴有明显的隐窝肥大和完整吸收不良的患者的绒毛绒毛。无麸质饮食和后续的空肠活检相结合证明了正常的粘膜结构最终得以恢复,因此对当代的定义提出了对粘膜愈合的相当严格的要求。

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