Mannose-binding protein, genetic variants and the risk of infection

摘要

Mannose-binding protein (MBP) has recently gained recognition as one of the important factors contributing to innate immunity. MBP deficiency is common, and affects around 30% of the population. Although many people with MBP deficiency appear untroubled by it, in some patients MBP deficiencies lead to recurrent and life-threatening infections. MBP is now included in the list of factors conferring genetic susceptibility to infections.