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Serodiagnosis of pericardial tuberculosis

机译:心包结核的血清学诊断

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The AIDS epidemic has led to the resurgence of tuberculosis. Extrapulmonary manifestations may appear in over half of the patients who are dually infected. This has resulted in a rising incidence of tuberculous pericarditis in several parts of Africa such as Tanzania. We tested a solid-phase antibody competition sandwich ELISA (SACT-SE) as a potential means of diagnosing tuberculous pericarditis. Fifty-one African patients with clinically diagnosed tuberculous pericardial effusion (of whom 25 had confirmation by pericardial fluid culture) were tested using a monoclonal antibody (CDC/WHO ref. no. IT39) which was raised against a specific epitope on the Mycobacterium tuberculosis 30 kDa antigen. All but one patient had negative sputum microscopy for acid-fast bacilli. A sensitivity of 61 % (at 96% specificity) was achieved. Sera from 25 African patients with smear-positive tuberculosis were also examined; of which 20 tested positive (sensitivity 80%). This is the largest study to date on the potential application of serology in diagnosing pericardial tuberculosis.
机译:艾滋病流行导致结核病重新流行。超过一半的双重感染患者可能出现肺外表现。这导致非洲一些地区(例如坦桑尼亚)结核性心包炎的发病率上升。我们测试了固相抗体竞争三明治ELISA(SACT-SE)作为诊断结核性心包炎的潜在手段。使用单克隆抗体(CDC / WHO参考号IT39)对51名临床诊断为结核性心包积液的非洲患者(其中25名通过心包液培养进行了确认)进行了检测,该抗体针对结核分枝杆菌上的特定表位而产生30 kDa抗原。除一名患者外,所有患者的抗酸杆菌痰镜检阴性。灵敏度为61%(特异性为96%)。还检查了25名非洲人涂阳肺结核患者的血清。其中20项测试呈阳性(灵敏度80%)。这是迄今为止有关血清学在心包结核诊断中潜在应用的最大研究。

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