Localization of iron transport and regulatory proteins in human cells

摘要

the recent discovery of HFE, the MHC-Class-I-Like gene mutated in up to 90/100 of patients with her- editary haemochromatosis, and the gene encoding the Nramp2/divalent metal transporter-1 (DMT-1) implicated in ferrous iron transport holds promise for a greater understanding of human iron meta- bolism. Since the HFE protein can be crystallized as a ternary complex with the transferrin receptor and iron-saturated transferrin, and DMT-1 expres- sion is up-regulated in hereditary haemochroma- tosis, these proteins are likely to interact in a common pathway for human iron homeostasis.