Polyherbal drug loaded starch nanoparticles as promising drug delivery system: Antimicrobial, antibiofilm and neuroprotective studies

摘要

Starch is a natural, renewable biopolymer widely used in pharmaceutical industry for the controlled release of drugs and hormones. Triphala Churna (TC) a tridoshic rasayana, rich in polyphenols and vitamin C possess balancing and rejuvenating effect on three constitutional elements that govern the human life. To enhance the solubility and efficiency of the ayurvedic drug TC, attempts were made to encapsulate the TC into starch biopolymers. Characterization of Starch Encapsulated Triphala Churna (SETC) by UV-Vis spectrum, showed a sharp absorption peak at 686 nm specific for polyherbal formulation. XRD analysis illustrated that SETC is amorphous in nature. Zeta potential and dynamic light scattering analysis illustrated that the SETC were highly stable at - 12 mV with an average size of 282.9 nm. SETC exhibited high drug encapsulation efficiency and fast drug release at physiological pH 7.4. Evaluation of neuroprotective effect illustrated that SETC showed excellent free radical scavenging activity, reducing power and acetylcholinesterase inhibitory activity. SETC also showed potent antibacterial activity (against Salmonella typhi and Shigella dysenteriae) and antibiofilm activity (against ATCC MRSA 33591 and clinical strain N7). Results conclude that TC on encapsulation with starch retained its antimicrobial, antibiofilm and neuroprotective activities illustrating starch as suitable drug delivery system.