Kiss-and-run, fuse-pinch-and-linger, fuse-and-collapse: The life and times of a neurosecretory granule

摘要

The fate of secretory membrane after fusion with the cell surface has been a subject of in-terest and considerable debate for almost 30 years. At nerve terminals, the limited number of synaptic vesicles and often high rates of action potential firing require that efficient machinery be in place to recover and replenish the vesicle pool to sustain the flow of information across the synapse over time. Since the first description of vesicle recycling at synapses, a debate about the nature of the machinery responsible for this task has persisted.