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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13
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Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13

机译:Pygopu​​s通过介体复合物亚基Med12和Med13激活Wingless目标基因转录

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摘要

Wnt target gene transcription is mediated by nuclear translocation of stabilized β-catenin, which binds to TCF and recruits Pygopus, a cofactor with an unknown mechanism of action. The mediator complex is essential for the transcription of RNA polymerase
机译:Wnt靶基因转录由稳定的β-catenin的核易位介导,该β-catenin与TCF结合并募集Pygopu​​s,Pygopu​​s是一种作用机理未知的辅因子。介体复合物对于RNA聚合酶的转录至关重要

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