A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT

Jie Hu; Ao Ma; Aaron R. Dinner

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A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT

机译：两步核苷酸翻转机制可通过AGT动力学识别DNA损伤

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O~6-alkylguanine-DNA alkyltransferase (AGT) repairs damage to the human genome by flipping guanine and thymine bases into its active site for irreversible transfer of alkyl lesions to Cys-145, but how the protein identifies its targets has remained unknow

机译：O〜6-烷基鸟嘌呤-DNA烷基转移酶（AGT）通过将鸟嘌呤和胸腺嘧啶碱基翻转到其活性位点以将烷基损伤不可逆地转移到Cys-145来修复对人类基因组的损害，但该蛋白质如何识别其靶点仍未知

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《Proceedings of the National Academy of Sciences of the United States of America》 |2008年第12期|4615-4620|共6页
作者
Jie Hu; Ao Ma; Aaron R. Dinner;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
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关键词
commitment probabilities; DNA repair; reaction coordinates; transition path sampling;

机译：承诺概率;DNA修复;反应坐标过渡路径采样;

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6. A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT [O] . Jie Hu, Ao Ma, Aaron R. Dinner 2008

机译：两步核苷酸翻转机制可通过AGT动力学识别DNA损伤
7. A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT [O] . Hu, Jie, Ma, Ao, Dinner, Aaron R. 2008

机译：两步核苷酸翻转机制可通过AGT动力学识别DNA损伤

A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT

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