机译:Parkin过表达选择针对异质cvbrid细胞中有害的mtDNA突变
Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892;
rnBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892;
rnBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892;
rnDepartment of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10065;
rnBiochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892;
autophagy; neurodegeneration; Parkinson disease; PINK1; mitochondria;
机译:帕金森氏病脑线粒体损害了呼吸道组装,与年龄相关的对mtDNA的氧化损伤分布增加,并且异质mtDNA突变丰度没有差异
机译:将具有NARP的患者的异质线粒体DNA(mtDNA)引入两个人类rho程度细胞系中,可能与NARP突变mtDNA的选择和维持或维持mtDNA的失败有关。
机译:核重编程过程中罕见的低水平异质性mtDNA突变的扩增导致人内诱导的多能干细胞变异
机译:在RNA中有害突变预测的有效方法的生物学意义上的扩展:插入和删除替代突变。
机译:遗传性血细胞化突变(C282Y和H63D)在家族性阿尔茨海默病和帕金森病中的涉及及其通过流行病致病选择所称的起源
机译:Parkin过表达选择针对异质杂交细胞中有害的mtDNA突变
机译:Parkin过表达选择针对异质杂交细胞中有害的mtDNA突变