Smg1 haploinsufficiency predisposes to tumor formation and inflammation

摘要

SMG1 is a member of the phosphoinosi-tide kinase-like kinase family of proteins whose other members, such as ATM, ATR, and mammalian target of rapa-mycin, are known to play roles in genomic stability and stress responses (1). SMG1 has a well-established role in a process known as nonsense-mediated decay (NMD), by which cells degrade mRNA transcripts that contain premature stop codons and limit the production of truncated proteins that may adversely affect cellular processes (2). SMG1 has also been proposed to play a role in telomere maintenance and the responses to DNA damage, hypoxia, and oxidative stress (3). In this study, we generated a mouse model of Smgl deficiency and found that Smgl KO mice died early during development. Smgl KO embryos were not identified 8.5 d postcoitum.