Double strand breaks at the HIS2 recombination hot spot in Saccharomyces cerevisiae

摘要

Double strand breaks (DSBs) have been found at several meiotic recombination hot spots in Saccha- romyces cerevisiae; more global studies have found that they occur at many places along several yeast chromosomes during meiosis. Indeed, the number of breaks found is consistent with the number of recombination events predicted from the ge- netic map. We have previously demonstrated that the HIS2 gene is a recombination hot spot, exhibiting a high frequency of gene conversion and associated crossing over.