首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain
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Isolation of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP ribosylation factor (ARF) 1 and ARF3 that contains a Sec7-like domain

机译:布雷菲德菌素A抑制的鸟嘌呤核苷酸交换蛋白针对ADP核糖基化因子(ARF)1和ARF3的分离,该蛋白含有Sec7样结构域

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摘要

Brefeldin A (BFA) inhibited the exchange of ADP ribosylation factor (ARF)-bound GDP for GTP by a Golgi-associated guanine nucleotide-exchange protein (GEP) [Helms, J. B. & Rothman, J. E. (1992) Nature (London) 360, 352-354; Donaldson, J. G., Finazzi, D. & Klausner, R. D. (1992) Nature (London) 360, 350-352]. Cytosolic ARF GEP was also inhibited by BFA, but after purification from bovine brain and rat spleen, it was no longer BFA-sensitive [Tsai, S.-C., Adamik, R., Moss, J. & Vaughan, M. (1996) Proc. Natl. Acad. Sci. USA 93, 305-309].
机译:布雷菲德菌素A(BFA)通过高尔基体相关的鸟嘌呤核苷酸交换蛋白(GEP)抑制了ADP核糖基化因子(ARF)结合的GTP的交换[Helms,JB&Rothman,JE(1992)Nature(London)360, 352-354; Donaldson,J.G.,Finazzi,D。&Klausner,R.D。(1992)Nature(London)360,350-352]。 BFA也可抑制胞质ARF GEP,但从牛脑和大鼠脾中纯化后,它不再对BFA敏感[Tsai,S.-C.,Adamik,R.,Moss,J.&Vaughan,M.( 1996),过程Natl。学院科学USA 93,305-309]。

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