Induction of cyclin D1 by simian virus 40 small tumor antigen

摘要

Cell-cycle progression is mediated by a co- ordinated interaction between cyclin-dependent kinases and their target proteins including the pRB and E2F/DP-1 com- plexes. Immunoneutralization and antisense experiments have established that the abundance of cyclin D1, a regulatory subunit of the cyclin-dependent kinases, may be rate-limiting for G_1 phase progression of the cell cycle. Simian virus 40 (SV40) small tumor (t) antigen is capable of promoting G_1 phase progression and augments substantially the efficiency of SV40 transformation through several distinct domains.