Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3

摘要

YY1 is a mammalian zinc-finger transcrip- tion factor with unusual structural and functional features. It has been implicated as a positive and a negative regulatory factor that binds to the CCATNTT consensus DNA element located in promoters of many cellular and viral genes. A mammalian cDNA that encodes a YY1-binding protein and possesses sequence homology with the yeast transcriptional factor RPD3 has been identified.