Ca~2+-induced rebound potentiation of γ-aminobutyric acid-mediated currents requires activation of Ca~2+/calmodulin-dependent kinase II

摘要

In cerebellar Purkinje neurons, γ-aminobu- tyric acid (GABA)-mediated inhibitory synaptic transmission undergoes a long-lasting "rebound potentiation" after the activation of excitatory climbing fiber inputs. Rebound po- tentiation is triggered by the climbing-fiber-induced transient elevation of intracellular Ca~2+ concentration and is expressed as a long-lasting increase of postsynaptic GABA_A receptor sensitivity. Herein we show that inhibitors of the Ca~2+/cal- modulin-dependent protein kinase II (CaM-KII) signal trans- duction pathway effectively block the induction of rebound potentiation.