首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Local nitric oxide production in viral and autoimmune diseases of the central nervous system.
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Local nitric oxide production in viral and autoimmune diseases of the central nervous system.

机译:在中枢神经系统的病毒性和自身免疫性疾病中产生一氧化氮。

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摘要

Because of the short half-life of NO, previous studies implicating NO in central nervous system pathology during infection had to rely on the demonstration of elevated levels of NO synthase mRNA or enzyme expression or NO metabolites such as nitrate and nitrite in the infected brain. To more definitively investigate the potential causative role of NO in lesions of the central nervous system in animals infected with neurotropic viruses or suffering from experimental allergic encephalitis, we have determined directly the levels of NO present in the central nervous system of such animals. Using spin trapping of NO and electron paramagnetic resonance spectroscopy, we confirm here that copious amounts of NO (up to 30-fold more than control) are elaborated in the brains of rats infected with rabies virus or borna disease virus, as well as in the spinal cords of rats that had received myelin basic protein-specific T cells.
机译:由于NO的半衰期短,以前的研究在感染过程中将NO牵涉到中枢神经系统病理中,因此必须依靠被感染的脑中NO合酶mRNA或酶表达水平升高或NO代谢产物(例如硝酸盐和亚硝酸盐)的证明。为了更明确地研究一氧化氮在感染嗜神经病毒或患有实验性变应性脑炎的动物中枢神经系统病变中的潜在致病作用,我们直接确定了这些动物中枢神经系统中一氧化氮的水平。使用NO的自旋俘获和电子顺磁共振波谱,我们在这里证实,在狂犬病病毒或博纳氏病病毒感染的大鼠的大脑中以及在狂犬病病毒中,脑中都富含大量的NO(比对照多30倍)。接受髓磷脂基础蛋白特异性T细胞的大鼠的脊髓。

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