首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >THE C-PROTEINASE THAT PROCESSES PROCOLLAGENS TO FIBRILLAR COLLAGENS IS IDENTICAL TO THE PROTEIN PREVIOUSLY IDENTIFIED AS BONE MORPHOGENIC PROTEIN-1
【24h】

THE C-PROTEINASE THAT PROCESSES PROCOLLAGENS TO FIBRILLAR COLLAGENS IS IDENTICAL TO THE PROTEIN PREVIOUSLY IDENTIFIED AS BONE MORPHOGENIC PROTEIN-1

机译:处理成纤维状胶原的过程中的C蛋白与先前被鉴定为骨致生蛋白1的蛋白是相同的

获取原文
获取原文并翻译 | 示例
       

摘要

Bone morphogenic protein-1 (BMP-1) was originally identified as one of several BMPs that induced new bone formation when implanted into ectopic sites in rodents. BMP-1, however, differed from other BMPs in that it its structure was not similar to transforming growth factor beta. Instead, it had a large domain homologous to a metalloendopeptidase isolated from crayfish, an epidermal growth-factor-like domain, and three regions of internal sequence homology referred to as CUB domains. Therefore, BMP-1 was a member of the ''astacin families'' of zinc-requiring endopeptidases. Many astacins have been shown to play critical roles in embryonic hatching, dorsal/ventral patterning, and early developmental decisions. Here, we have obtained amino acid sequences and isolated cDNA clones for procollagen C-proteinase (EC 3.4.24.19), an enzyme that is essential for the processing of procollagens to fibrillar collagens. The results demonstrate that procollagen C-proteinase is identical to BMP-1. [References: 33]
机译:骨形态发生蛋白-1(BMP-1)最初被确定为几种BMP之一,当它们被植入啮齿动物的异位部位时会诱导新的骨形成。但是,BMP-1与其他BMP的不同之处在于其结构与转化生长因子β不同。相反,它具有一个与从小龙虾分离的金属内肽酶同源的大结构域,一个表皮生长因子样结构域和三个内部序列同源性区域,称为CUB结构域。因此,BMP-1是需要锌的内肽酶的“ astacin家族”的成员。已显示许多葡萄球菌素在胚胎孵化,背/腹模式和早期发育决定中起关键作用。在这里,我们获得了胶原蛋白C蛋白酶的氨基酸序列和分离的cDNA克隆(EC 3.4.24.19),胶原蛋白是胶原蛋白原纤维加工所必需的一种酶。结果表明前胶原C蛋白酶与BMP-1相同。 [参考:33]

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号