首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >SYNAPTOPHYSIN, A MAJOR SYNAPTIC VESICLE PROTEIN, IS NOT ESSENTIAL FOR NEUROTRANSMITTER RELEASE
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SYNAPTOPHYSIN, A MAJOR SYNAPTIC VESICLE PROTEIN, IS NOT ESSENTIAL FOR NEUROTRANSMITTER RELEASE

机译:突触素是一种主要的突触囊泡蛋白,对于神经递质的释放不是必需的

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摘要

Synaptophysin (syp I) is a synaptic vesicle membrane protein that constitutes approximate to 7% of the total vesicle protein. Multiple lines of evidence implicate syp I in a number of nerve terminal functions. To test these, we have disrupted the murine syp I gene, Mutant mice lacking syp I were viable and fertile. No changes in the structure and protein composition of the mutant brains were observed except for a decrease in synaptobrevin/VAMP II. Synaptic transmission was normal with no detectable changes in synaptic plasticity or the probability of release. Our data demonstrate that one of the major synaptic vesicle membrane proteins is not essential for synaptic transmission, suggesting that its function is either redundant or that it has a more subtle function not apparent in the assays used. [References: 33]
机译:突触素(syp I)是一种突触囊泡膜蛋白,约占总囊泡蛋白的7%。多行证据暗示syp I在许多神经末梢功能中起作用。为了测试这些,我们破坏了鼠的syp I基因,缺少syp I的突变小鼠是活的和可育的。除了突触短纤维蛋白/ VAMP II的减少,没有观察到突变脑的结构和蛋白质组成的变化。突触传递是正常的,没有可察觉的突触可塑性或释放概率变化。我们的数据表明,主要的突触小泡膜蛋白之一对于突触传递不是必需的,这表明其功能要么多余,要么具有更细微的功能,在所用的测定法中不明显。 [参考:33]

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