CRYSTAL STRUCTURE OF A HUMAN TATA BOX-BINDING PROTEIN/TATA ELEMENT COMPLEX

摘要

The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct Initiation of transcription of ribosomal. messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 Angstrom resolution, Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-Angstrom-resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box. [References: 31]