Powder X-ray diffraction of varenicline hydrogen tartrate Form B (Chantix®),(C_(13)H_(14)N_3)(HC_4H_4O_6)

摘要

The crystal structure of varenicline hydrogen tartrate Form B (Chantix(R)) has been refined using synchrotron X-ray powder diffraction data and optimized using density functional techniques. Varenicline hydrogen tartrate Form B crystallizes in space group P2(1)2(1)2(1) (#19) with a = 7.07616(2), b = 7.78357(2), c = 29.86149(7) angstrom, V = 1644.706(6) angstrom(3), and Z = 4. The hydrogen bonds were identified and quantified. Hydrogen bonds link the cations and anions in zig-zag chains along the b-axis. The powder pattern has been submitted to ICDD(R) for inclusion in the Powder Diffraction File (TM) (PDF (R)). (C) The Author(s), 2021. Published by Cambridge University Press on behalf of International Centre for Diffraction Data.