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摘要

Nanomaterials based on DNA have found much attention due to their programmability and availability. However, natural base-pairs of DNA have little attractive character as materials. We have proposed a novel design of pseudo base-pairs, in which non-natural molecules were introduced into base-pairing position of the DNA duplex via D-threoninol. Artificial DNA exhibiting unique properties was successfully prepared with this design principles. For example, a fluorescence switchable pair between perylene and anthraquinone was prepared, and this pair was used for the detection of target DNA/RNA. Photodimerization of stilbene derivatives was used for photocrosslinking of the DNA duplex. A non-planar pair of cyclohexane derivatives suppressed electron/hole transfer in the DNA duplex. Now we are applying these pairs to prepare functional nanomaterials based on DNA.