Enhanced Osteoblast Adhesion To Epoxide-functionalized Surfaces

摘要

Microstructuring of biomaterials has become an important field of research, e.g. the creation of surface patterns on biomaterials in order to control protein and cell interactions. In their recent work K. D. Jandt et al. succeed in functionaliz-ing glass substrates with an epoxidernmonolayer that show protein-binding properties. These cell-binding properties are compared with the generally applied extracellular matrix (ECM) proteins and it can be observed that epoxide-functionalized SAM performs better than ECM gel. This provides new routes for very cost-effective systems that improve biocompatibility as well as exciting, new methodologies to control and direct cell adhesion.