Effect of Direction (Epidermis-To-Dermis and Dermis-To-Epidermis) on the Permeation of Several Chemical Compounds through Full-Thickness Skin and Stripped Skin

摘要

Compound permeation through stratum corneum-stripped skin is generally greater than that through full-thickness skin. In addition, epidermis-to-dermis permeation profile should be the same as dermis-to-epidermis permeation profile. However, stripped skin permeability of some compounds was lower than full-thickness skin permeability and different permeabilities were found for some compounds between the two directions of skin permeation. The reasons for these findings were investigated in this study.