Practical, general, and systematic method for optical resolution of gem-dihalo- and monohalocyclopropanecarboxylic acids utilizing chiral 1,1'-binaphtholmonomethyl ethers: Application to the synthesis of three chiral pesticides

摘要

We performed an efficient practical and systematic optical resolution method for gem-dihalo- and monohalocyclopropanecarboxylic acids 1 and 5 utilizing chiral 1,1'-binaphthol monomethyl ether (R)-2 as the key auxiliary. Direct esterification of 1 with (R)