Palladium-catalyzed ortho-acyloxylation of N-nitrosoanilines via direct sp~2 C-H bond activation

摘要

The palladium-catalyzed N-nitroso-directed ortho-acyloxylation of N-nitrosoanilines has been demonstrated via sp~2 C-H activation with a stoichiometric amount of Phl(OAc)_2 as the oxidant and Ac_2O/AcOH (1:1) or C_2H_5CO_2H as the reaction medium. This protocol can be applied to various N-nitrosoanilines with both electron-donating and electron-withdrawing groups. In addition, the products can be further transformed to 2-(methylamino)phenols expediently by a simple reduction method.