Synthesis of 1,3,5-triazines via Cu(OAc)_2-catalyzed aerobic oxidative coupling of alcohols and amidine hydrochlorides

摘要

Cu(Oac)_2 was found to be an efficient catalyst for dehydrogenative synthesis of 1,3,5-triazine derivatives via oxidative coupling reaction of amidine hydrochlorides and alcohols in air. Both aromatic and aliphatic alcohols can be involved in the reaction and thirty-three products were obtained with good to excellent yields. Moreover, the use of a ligand, strong base and organic oxidant is unnecessary.