Studies on tridecaptin B_1, a lipopeptide with activity against multidrug resistant Gram-negative bacteria

摘要

Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type ⅡA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B_1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B_1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.