Light controllable TiO_2-Ru nanocomposite system encapsulated in phospholipid unilamellar vesicles for anti-cancer photodynamic therapy

摘要

Photodynamic therapy implies a combined use of a photosensitizing medicament and low-intensity light to cause selective damage to the target tissue-tumor. As potential medicament, we use Ru(II)(dcbpy)(2)Cl-2 complex, and in order to achieve better photosensitization properties, the Ru complex was attached to the nano carrier-TiO2 nanoparticles. Additionally, this nanocomposite system was encapsulated in the phospholipid vesicles, which could be classified as small unilamellar vesicles, based on the technique of production. The complex-release tests were performed under light illumination, at pH 5, characteristic for tumor cells' interior and compared with the release pattern at pH 7, characteristic for the serum, i.e. physiological solution.