Synthesis and radioiodinated labeling of p-iodophenyl pentadecanoic acid

摘要

A new method for the preparation of p-iodophenyl pentadecanoic acid(IPPA) has been developed. The synthesis are described, and physical properties of IPPA are char- acterized by IR, ~1HNMR, elementary analysis and MS. ~125I-IPPA can be easily prepared by two methods: direct labeling and solid-phase iodo-exchange labeling, and the yields of labeling are 80/100 and 65/100, respectively. The radiochemical purities are higher than 98/100 after being extracted with chloroform and hexane.