Preclinical pharmacological study on ~125I-IPPA

摘要

Myocardial uptake of ~125I-IPPA in rats showed a peak of 4.4/100 of injected dose per gram. The half elimination time of myocardium was 3.8 min and the maximal uptake of thyroid is only 0.005/100 ID/organ at 120 min. The initial half time of 2.7 min in rabbits was obtained from the elimination curve of radioactivity in blood. In vitro binding test for ~125I- IPPA to HAS showed rather constant level of activation during two hours.