Influencing factors of radioiodine therapy in hyperthyroidism in adults

摘要

The study was to evaluate factors affecting outcome of ~(131)I therapy in hyperthyroidism for optimizing the method. Data from 213 patients who received ~(131)I treatment from July 2003 to July 2005 in our department were retrospectively analyzed. Factors possibly contributing to the outcome of the ~(131)I therapy were analyzed, including gender, age, history of antithyroid drug, thyroid volume, duration of disease and radioactive iodine uptake rate. Multivari-ate analysis was done. The rates of euthyroidism and hypothyroidism were 69% and 8.5%, respectively, after one time ~(131)I therapy. Multivariate analysis of the patients showed no statistically significant factors affecting the outcome of ~(131)I therapy. The study showed that ~(131)I dose can be directly calculated, and this simplifies the dose-determined method and individualizes the therapy.