Differences in the expression profiles of normal contralateral tissues of papillary thyroid cancer patients exposed and not exposed to the Chernobyl fallout

摘要

In populations exposed to radiation, only a fraction of exposed individuals develop cancer. This might be due to either a stochastic phenomenon (chance event) or to a predisposition of some individuals. We have investigated these hypotheses. Papillary thyroid cancer (PTCs) incidence increased dramatically in children after the Chernobyl accident, providing a unique large panel of radio-induced solid tumors. Most studies of this material, however, have so far been limited by the lack of age-matched non-irradiated PTC patients, from the same geographical area.