Biodegradable radioactive implants for glaucoma filtering surgery produced by ion implantation

摘要

A biodegradable, β-emitting implant has been developed and successfully tested which prevents fresh intraocular pressure increase after glaucoma filtering surgery. Ion implantation has been used to load the polymeric implants with the β-emitter ~(32)P. The influence of ion implantation and gamma sterilisation on degradation and ~(32)P-fixation behavior has been studied by ion beam and chemical analysis. Irradiation effects due to the applied ion fluence (10~(15) ions/cm~2) and gamma dose (25 kGy) are found to be tolerable.