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Development of an adjustable beam flattening system for modification of passive beam delivery technique in proton therapy

机译:改进可调节束展平系统以改进质子治疗中的被动束传输技术

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摘要

The purpose of this work is to introduce a simple method for the maximization of beam intensity on the target volume in proton therapy based on passive beam delivery system. In this method, the treatment area of the lateral beam profile is adjusted with the lateral size of the target to maximize the contribution of protons in target bombarding in order to achieve a more effective treatment. For this aim, an adjustable beam flattening system was designed to modify dose delivery by creating any arbitrary lateral homogeneous dose profile, using multi-foil scattering and beam wobbling systems. The multi-foil scattering system includes several uniform scatterer foils with different thicknesses. By this system the proper scatterer foil is automatically inserted in front of the incident proton beam for each treatment. The adjustable beam flattening system is controlled by a computer program developed with several options. This program allows the user to create the desired flat beam profile by providing the best scatterer thickness and an appropriate beam deflection angle, where both are fundamental parameters in the flat dose profile generation.
机译:这项工作的目的是介绍一种基于被动束传输系统的在质子治疗中最大化目标体积上的束强度的简单方法。在这种方法中,可以根据目标的横向尺寸调整侧向射束轮廓的治疗区域,以最大化质子在轰击目标中的贡献,从而实现更有效的治疗。为了这个目的,设计了一种可调节的光束展平系统,使用多箔散射和光束摆动系统,通过创建任意的横向均质剂量分布图来修改剂量的输送。多箔散射系统包括多个具有不同厚度的均匀散射箔。通过该系统,对于每次处理,将适当的散射箔自动插入到入射质子束的前面。可调光束展平系统由计算机程序控制,该计算机程序开发了多个选项。该程序允许用户通过提供最佳散射体厚度和适当的光束偏转角来创建所需的平坦光束轮廓,这两者都是平坦剂量轮廓生成中的基本参数。

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  • 作者单位

    Centro Nazionale di Adroterapia Oncologia CNAO, Strada Privata Campeggi, Pavia 27100, Italy;

    Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-6-01-2, Sendai 980-8579, Japan;

    Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-6-01-2, Sendai 980-8579, Japan;

    Cyclotron and Radioisotope Center, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-3, Sendai 980-8579, Japan;

    Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-6-01-2, Sendai 980-8579, Japan;

    Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-6-01-2, Sendai 980-8579, Japan;

    Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-6-01-2, Sendai 980-8579, Japan;

    Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-6-01-2, Sendai 980-8579, Japan;

    Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-6-01-2, Sendai 980-8579, Japan;

    Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-6-01-2, Sendai 980-8579, Japan;

    Department of Quantum Science and Energy Engineering, Graduate School of Engineering, Tohoku University, Aoba-ku, Aramaki Aza-Aoba 6-6-01-2, Sendai 980-8579, Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    passive beam delivery modification; adjustable beam flattening system; proton therapy;

    机译:被动光束传输修改;可调光束展平系统;质子治疗;

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