Biopysical model of axonal pathfinding

摘要

Axonal pathfinding is an important feature of embryonary development. Based on many biological references. Both motor and sensorial function of neurite outgrowth were modelled. The kinetics of filopodia was first described according to their intrinsic motion. The dynamic of The neurite was then simulated with both a visco-elastic elongation, due to the tensions exerted By the growth cone, and a pure outgrowth process, represent in the polymerization of the Microtubules. Finally, assumptions were made on how filoposia could sense a gradient and be Reorganized in an asymmetric distributional. The model reproduces quite well the experimental Trajectory of a neurite plunged in a gradient of diffuse molecules.