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A Monte Carlo analysis of calcium dynamics and facilitation

机译:钙动力学和促进的蒙特卡洛分析

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A Monte Carlo analysis is made of calcium dynamics and quantal secretion at active zones of varicosities and boutons following multiple channels opening under trains of action potentials. Endogenous fixed and mobile buffers are included, as are calcium pumps in the terminal walls. For a stimulation frequency of 100 Hz there is considerable facilitation due to residual binding Of calcium to vesicle-associated proteins and to an increase in the residual free caolcium in The terminal, but this effect disappears for stimulation frequencies of less that 50 Hz, indicating That additional mechanisms are needed to explain the longer-lasting components of facilita- Tion.
机译:蒙特卡洛分析是在一系列动作电位作用下打开多个通道后,对静脉曲张和纽扣活跃区的钙动力学和定量分泌进行的。包括内源固定和移动缓冲液,以及末端壁中的钙泵。对于100 Hz的刺激频率,由于钙与囊泡相关蛋白的残留结合以及末端中残留的游离钙的增加而大大简化了操作,但是对于小于50 Hz的刺激频率,这种影响消失了,表明需要额外的机制来解释促进作用的更持久的组成部分。

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