The Ornstein-Uhlenbeck Process Does Not Reproduce Spiking Statistics of Neurons in prefrontal Cortex

摘要

Cortical neurons of behaving animals generate irregular spike sequences. Recently, there has been a heated discussion about the origin of this ir- Regularitry. Softky and Koch (1993) pointed out the inability of standard Single-neuron models to reproduce the irregularity of the observed spike Sequences when the model parameters are chosen within a certain range That they consider to be plausible. Shadlen and Newsome (1994), on the Other had, demonstrated that a standard leaky integrate-and-fire model Can reproduce the irregularity if the inhibition is balanced with the exci- Tation.