KCO912: a potent and selective opener of ATP-dependent potassium (KATP) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects

摘要

ATP-sensitive potassium (KATP) channel openers can obviate experimental airways hyperreactivity (AHR) and have shown therapeutic benefit in asthma. However, the clinical potential of such compounds has been compromised by cardiovascular side-effects. We report here the pharmacological properties of (3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-piperidinyl)-N-phenyl-2H-1-benzopyran-6-sulphonamide (KCO912), a KATP channel opener which suppresses AHR at doses devoid of cardiovascular effects.