Hsp72 in muscular dystrophy

摘要

The absence of the membrane-stabilizing protein dystrophin in patients with Duchenne muscular dystrophy results in a highly fragile sarcolemma, abnormal handling of cytoplasmic calcium ions and muscle degeneration. Stefan Gehrig et al. test the idea that enhanced intramuscular expression of heat shock protein 72 (Hsp72) might reduce the pathophysiology of muscular dystrophy in two mouse models of the disease.