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Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism

机译:膜中二十二碳六烯酸(DHA)的含量决定了钠泵的分子活性:对疾病状态和代谢的影响

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摘要

The omega-3 polyunsaturate, docosahexaenoic acid (DHA), plays a number of biologically important roles, particularly in the nervous system, where it is found in very high concentrations in cell membranes. In infants DHA is required for the growth and functional development of the brain, with a deficiency resulting in a variety of learning and cognitive disorders. During adulthood DHA maintains normal brain function and recent evidence suggests that reduced DHA intake in adults is linked with a number of neurological disorders including schizophrenia and depression. Here we report a high positive correlation between the molecular activity (ATP min~(-1)) of individual Na~+K~+ATPase units and the content of DHA in the surrounding membrane bilayer. This represents a fundamental relationship underlying metabolic activity, but may also represent a link between reduced levels of DHA and neurological dysfunction, as up to 60% of energy consumption in the brain is linked to the Na~+K~+ATPase enzyme.
机译:ω-3多不饱和二十二碳六烯酸(DHA)在生物学上起着重要作用,尤其是在神经系统中,在细胞膜中浓度很高。婴儿DHA是大脑生长和功能发育所必需的,缺乏DHA会导致各种学习和认知障碍。在成年期间,DHA维持正常的大脑功能,最近的证据表明,成年人DHA摄入减少与许多神经系统疾病有关,包括精神分裂症和抑郁症。在这里,我们报道了单个Na〜+ K〜+ ATPase单位的分子活性(ATP min〜(-1))与周围膜双层中DHA含量之间的高度正相关。这代表了代谢活动的基本关系,但也可能代表DHA水平降低与神经功能障碍之间的联系,因为大脑中多达60%的能量消耗与Na〜+ K〜+ ATPase酶有关。

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