A type III polyketide synthase from Rhizobium ettt condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency

Marimuthu Jeya; Tae-Su Kim; Manish Kumar Tiwari; Jinglin Li; Huimin Zhao; Jung-Kul Lee

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A type III polyketide synthase from Rhizobium ettt condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency

机译：根瘤菌属的III型聚酮化合物合酶以异常高的催化效率将丙二酰辅酶A缩合为庚酮

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A novel type III polyketide synthase (RePKS) from Rhizobium etli produced a heptaketide pyrone using acetyl-CoA and six molecules of malonyl-CoA. Its catalytic efficiency (k_(cat)t/K_m = 5230 mM~(-1) min~(-1)) for malonyl Co A was found to be the highest ever reported. Molecular dynamics studies revealed the unique features of RePKS.

机译：来自根瘤菌的新型III型聚酮化合物合酶（RePKS）使用乙酰辅酶A和六个分子的丙二酰辅酶A产生了七肽吡喃酮。发现其对丙二酰辅酶A的催化效率（k_（cat）t / K_m = 5230 mM〜（-1）min〜（-1））是有史以来最高的。分子动力学研究揭示了RePKS的独特功能。

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《Molecular BioSystems》 |2012年第12期|3103-3106|共4页
作者
Marimuthu Jeya; Tae-Su Kim; Manish Kumar Tiwari; Jinglin Li; Huimin Zhao; Jung-Kul Lee;
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Department of Chemical Engineering, Konkuk University, Seoul 143-701, Korea;

Department of Chemical Engineering, Konkuk University, Seoul 143-701, Korea;

Department of Chemical Engineering, Konkuk University, Seoul 143-701, Korea;

Department of Chemical Engineering, Konkuk University, Seoul 143-701, Korea;

Departments of Chemical and Biomolecular Engineering, Chemistry, and Bioengineering, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA,Institute for Genomic Biology, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA,Center for Biophysics and Computational Biology, University of Illinois, 600 South Mathews Avenue, Urbana, IL 61801, USA;

Department of Chemical Engineering, Konkuk University, Seoul 143-701, Korea;

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4. Benzoic Acid-Specific Type III Polyketide Synthases [C] . L. Beerhues, B. Liu, T. Raeth, American Chemical Society . 2006

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A type III polyketide synthase from Rhizobium ettt condenses malonyl CoAs to a heptaketide pyrone with unusually high catalytic efficiency

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